Aneurysmal bone cyst (ABC) is a very rare, benign, non-neoplasic lession that tipically ocurs in the early life, usually before the 3rd decade, it's exceptional in youngers than 10 years. We report the diagnosis and treatment of an 8 years old girl with an ABC in the left temporal bone, a very unusual location. Although the histologic caracteristics have been well defined, its pathogenesis remains obscure and not totally explained. Total excision nowadays is the treatment of choice.

El quiste óseo aneurismático (QOA) es una lesión muy infrecuente, de carácter benigno, no neoplásica que aparece típicamente en edades tempranas de la vida, usualmente antes de la 3ª década de vida, siendo excepcional en menores de 10 años. Exponemos el diagnóstico y tratamiento de una niña de 8 años con un QOA del hueso temporal izquierdo, una localización poco frecuente. Aunque las características histológicas están bien definidas, su etiopatogenia aún no ha sido totalmente explicada. Actualmente la exéresis completa es el tratamiento de elección.

CONTEXTUALIZAÇÃO: O aumento de doenças crônicas em idosos, principalmente da Hipertensão Arterial Sistêmica, doença intimamente relacionada ao declínio da capacidade funcional, determina a necessidade do estudo de métodos de avaliação da realização das atividades, possibilitando detecção de níveis de capacidade funcional, prescrição de exercícios e acompanhamento das funções cardiovascular e motora. O teste da caminhada de 6 minutos (TC6'), o teste da Marcha Estacionária de 2 minutos (TME2') e o teste Timed Up and Go (TUG) são indicados para esta avaliação. Estudos em idosos saudáveis mostram a associação entre esses testes, facilitando a avaliação da capacidade funcional. Porém, em hipertensos, não existem estudos que avaliem a relação entre TC6', TME2'e TUG, justificando a realização desta pesquisa. OBJETIVOS: Verificar se existe associação entre endurance aeróbia e a mobilidade funcional em idosas hipertensas. MÉTODOS: Estudo observacional, analítico e transversal, com 32 hipertensas idosas, avaliadas por meio do TC6', TME2' e TUG. RESULTADOS:Houve correlação positiva moderada entre TC6' e TME2', r=0,36 (p=0,04) e correlação negativa moderada entre TC6'e TUG, r=-0,59 (p=0,000) e entre TME2' e TUG, r=-0,66 (p=0,000). CONCLUSÕES: Para hipertensas idosas, o TC6' pode ser substituído pelo TME2', assim como em idosos saudáveis. Quanto à correlação entre os TC6', TME2' e TUG, pode-se concluir que existe uma íntima relação entre resistência cardiovascular e mobilidade funcional; havendo menor resistência cardiovascular, há mobilidade funcional precária e vice-versa.

BACKGROUND: The increase in chronic diseases among older adults, especially systemic arterial hypertension, a disease that is closely related to declining functional capacity, has created the need to study methods for activity evaluation in order to detect functional capacity levels, prescribe exercises and monitor motor and cardiovascular function. The Six-Minute Walk Test (6MWT), Two-Minute Step Test (2MST) and Timed Up and Go Test (TUG) are indicated for such evaluations. Studies among healthy older adults have shown associations between these tests, thus aiding the evaluation of functional capacity. However, there are no studies on the relationships between the 6MWT, 2MST and TUG among hypertensive individuals, thus justifying the present research. OBJECTIVES: To investigate whether there is any association between aerobic endurance and functional mobility among hypertensive older women. METHODS:This was a cross-sectional observational and analytical study on 32 hypertensive older women who were evaluated using the 6MWT, 2MST and TUG. RESULTS:There was a moderate positive correlation between the 6MWT and 2MST (r=0.36; p=0.04), and there were moderate negative correlations between the 6MWT and TUG (r=-0.59; p=0.000) and between the 2MST and TUG (r=-0.66; p=0.000). CONCLUSIONS: For hypertensive older women, the 6MWT can be replaced by the 2MST; the same applied to healthy older adults. Regarding the correlation between the 6MWT, 2MST and TUG, it can be concluded that there is a close relationship between cardiovascular endurance and functional mobility. When there is lower cardiovascular endurance, there is precarious functional mobility and vice versa.

Alkaline phosphatase (ALP) is important in calcification and its expression seems to be associated with the inflammatory process. We investigated the in vitro acute effects of compounds used for the prevention or treatment of cardiovascular diseases on total ALP activity from male Wistar rat heart homogenate. ALP activity was determined by quantifying, at 410 nm, the p-nitrophenol released from p-nitrophenylphosphate (substrate in Tris buffer, pH 10.4). Using specific inhibitors of ALP activity and the reverse transcription-polymerase chain reaction, we showed that the rat heart had high ALP activity (31.73 ± 3.43 nmol p-nitrophenol·mg protein-1·min-1): mainly tissue-nonspecific ALP but also tissue-specific intestinal ALP type II. Both ALP isoenzymes presented myocardial localization (striated pattern) by immunofluorescence. ALP was inhibited a) strongly by 0.5 mM levamisole, 2 mM theophylline and 2 mM aspirin (91, 77 and 84%, respectively) and b) less strongly by 2 mM L-phenylalanine, 100 mL polyphenol-rich beverages and 0.5 mM progesterone (24, 21 to 29 and 11%, respectively). β-estradiol and caffeine (0.5 and 2 mM) had no effect; 0.5 mM simvastatin and 2 mM atenolol activated ALP (32 and 36%, respectively). Propranolol (2 mM) tended to activate ALP activity and corticosterone activated (18%) and inhibited (13%) (0.5 and 2 mM, respectively). We report, for the first time, that the rat heart expresses intestinal ALP type II and has high total ALP activity. ALP activity was inhibited by compounds used in the prevention of cardiovascular pathology. ALP manipulation in vivo may constitute an additional target for intervention in cardiovascular diseases.